Computational approaches for Oral bioavailability prediction: An overview

High oral bioavailability is among the most important consideration during drug development process. Oral-bioavailability is usually determined in the pre-clinical stage of drug development process. It was found that 30% of drugs fail during the drug discovery process. Therefore there is a need of a robust and accurate computational model which can predict the oral bioavailability of compounds without carrying out any experiments. There exists a plethora of studies to predict oral bioavailability which indicates that it is incredibly rich area of research. Various attempts in estimating oral bioavailability are reported in literature belonging to different categories. In this article computational oral bioavailability prediction approaches are discussed.