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Sensors  2013 

Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

DOI: 10.3390/s130303242

Keywords: microstructured polymer optical fiber, fluorescence, antibodies

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Abstract:

We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.

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