Adult population as potential reservoir of NTD infections in rural villages of Kwale district, Coastal Kenya: implications for preventive chemotherapy interventions policy

A total of 599 adults in the 5 study villages were tested for NTD infections in urine, stool and blood. The presence of Schistosoma haematobium infection was determined by the urine filtration method. The presence of STH in stool was determined by Kato-Katz method while filarial antigenaemia was determined using immunochromatographic (ICT) test.The study revealed high prevalence of hookworm (41.7%) and schistosomiasis (18.2%) infections among adults in the study villages. Of the 599 individuals examined, 50.1% had one or more helminthic infections. There was low level of polyparasitism with helminthic NTDs in the study population with 9.5% and 1.7% of the participants having two and three infections, respectively.In the current study, hookworm and schistosomiasis infections were identified as important infections among adults living in areas of high endemicity for these infections. Thus, if this section of the population is left untreated it may remain an important potential reservoir and a source of re-infection for school-age children treated in school deworming programmes. Therefore, there is a need to design novel strategies for preventive chemotherapy interventions that could allow inclusion of adults in an effort to reduce force of infection in high endemic communities.Neglected tropical diseases (NTDs) include seven helminth infections namely soil-transmitted helminths (STH) infections (hookworm, ascariasis, trichuriasis), lymphatic filariasis (LF), onchocerciasis, guinea worm disease (dracunculiasis), and schistosomiasis [1]. Soil-transmitted helminths (STH) and schistosomiasis are mostly prevalent in developing countries due to poor sanitation and lack of adequate clean water. Soil-transmitted helminth infections are among the most prevalent infections in the world with around 1.4 billion individuals infected by Ascaris lumbricoides, 1.0 billion by Trichuris trichiura, and 1.3 billion by hookworms [2]. Of an estimated 200 million people infected with schist