Role of Myeloperoxidase in Stroke

Ischemic stroke is a significant pathological state which results from sudden infract in brain tissue. Most common cause of ischemic stroke is atherosclerosis. It is the most common cause of mortality in developed countries. Atherosclerosis has been purposed to be a chronic inflammatory disease. There is significant association between inflammatory process and ischemic events. Oxidative stress and inflammation significantly contribute to development of atherosclerosis. Myeloperoxidase enzyme is a lysosomal enzyme secreted from leucocytes as a response to oxidative stress. MPO which has been abundantly present in leucocytes, forms reactive oxidant products and plays role in atherosclerotic reactions thorough its catalytic activity. [Archives Medical Review Journal 2013; 22(1.000): 1-11]