Removal from the plasma of the free and esterified forms of cholesterol and transfer of lipids to HDL in type 2 diabetes mellitus patients

14C- cholesteryl ester FCR of the nanoemulsion was greater in T2DM than in controls (0.07？±？0.02 vs. 0.05？±？0.01？h-1, p？=？0.02) indicating that LDE was removed faster, but FCR 3？H- cholesterol was equal in both groups. Esterification rates of LDE free-cholesterol were equal. Cholesteryl ester and triglyceride transfer from LDE to HDL was greater in T2DM (4.2？±？0.8 vs. 3.5？±？0.7%, p？=？0.03 and 6.8？±？1.6% vs. 5.0？±？1.1, p？=？0.03, respectively). Phospholipid and free cholesterol transfers were not different.The kinetics of free and esterified cholesterol tended to be independent in T2DM patients and the lipid transfers to HDL were also disturbed. These novel findings may be related with pathophysiological mechanisms of diabetic macrovascular disease.