A Study on Tuberculous Pleural Effusion

Background: Nearly one third of the global population i.e. two billion people are infected with mycobacteria tuberculosis and are at risk of developing the disease. Pleural effusion is one of the common complications of pulmonary tuberculosis. In this study, the clinical features, the positivity rate of microbiological procedures and blind pleural biopsies, radiological manifestations, biochemical and hematological profiles of serum and pleural fluid were analyzed. Objectives: To report our experience of 108 patients with tuberculous pleural effusion and discuss the clinical features, radiological findings, biochemical, cytological and microbiological analysis of pleural fluid, hematological and biochemical profiles of serum and positivity rate of microbiological procedures and blind pleural biopsies in these patients. Methods: This study was a hospital based descriptive cross sectional study performed at Chest Medical Ward, Yangon General Hospital, Myanmar, of study period from January 2004 through January 2005. A total of 108 patients were included. Thorough history taking and physical examinations, radiological findings, hematological and serum biochemical profiles were recorded. Pleural aspiration and biopsy were also performed. At least two pieces of pleural tissue were taken and one piece of each sample of pleural tissue was cultured for mycobacteria and the rest was sent for histological examination. Macroscopic findings, cytological, microbiological and biochemical analysis of pleural fluid were analyzed. Results: A total of 108 patients, 74 males and 34 females were included. Their mean age was 42.60 ± 16.34 (range 12-81 years). Common presentations were breathlessness (82.4%), cough (81.5%), fever (80.6%), and night sweat (78.7%), loss of appetite (74.1%), significant weight loss (72.2%) and chest pain (67.6%). Only 39.3% of TB patients produced sputum in their history. Haemoptysis was present in only 7.4% of the patients. Regarding the physical signs, 53.7% of them had fever during admission, 15.7% were cachexic, cervical lymph nodes were palpable in 14.8% and had clubbing of fingers in 5.6%. They also had respiratory physical signs other than pleural effusion which include crepitation (31.5 %), collapse (15.7 %), pleural rub (13.0 %) and signs of consolidation (11.1 %). Only one patient (0.9%) had positive AFB smear in pleural fluid. Culture of pleural effusion and pleural biopsy reports for AFB were positive in 5.6% and 1.9% respectively. 91 patients (84.3 %) were diagnosed on first biopsy procedure and 15 (13.8%) and 2 (1.9 %) of patients n