CENTRAL NERVOUS SYSTEM DEPRESSANT ACTIVITY OF AQUEOUS EXTRACT OF CISSUS QUADRANGULARIS

The research work deals with the screening of aqueous extracts of Cissus quadrangularis (CQ) stem for central nervous system (CNS) depressant activity. The CQ leaves and stems contain resveratrol, piceatannol, pallidol perthenocissin derivatives as chemical components and are reported to have anticonvulant activity. The extract of plant showed GABAA- benzodiazepine receptor binding activity we made an attempt to study its CNS depressant effect. The different activities studied were test for locomotor activity, effect on muscle co-ordination, antiaggressive and antianxiety activities. The result of the study reflected that aqueous extract of the stem (150 mg/kg, p.o) decreased locomotor activity, produced muscle relaxation and showed antianxiety and antiaggressive activity