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Inhibition of Aldose Activity by Essential Phytochemicals of Cymbopogon citratus (DC.) Stapf

Keywords: Aldose Reductase , Molecular Docking , Citral , Geraniol , Myrcene , Cymbopogon citratus

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Abstract:

The ambiguity of whether aldose reductase, an enzyme of polyol pathway, is linked to diabetesand its complication has been receded based on the recent studies made on the inhibition of its(Aldose reductase) activity. In our current study, we have used an in silico approach (moleculardocking) to analyze the effect of essential phytochemicals obtained from Cymbopogon citratus onthe aldose reductase activity. C.citratus is grown extensively in tropical countries including Indiafor perfumery and pharmaceuticals. The essential phytochemicals of C.citratus like Myrcene,Citral, and Geraniol have been used as ligand for the molecular docking analysis with Aldosereductase as receptor. The docking analysis showed Myrcene, with binding energy of -8.76Kcal/mol is best amongst Citral and Geraniol which are having binding energies of -7.24 Kcal/moland -7.93 Kcal/mol respectively for inhibiting the activity of Aldose reductase.

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