ANTIULCER ACTIVITY OF METHANOLIC LEAVES EXTRACT OF NERIUM INDICUM MILL.

The objective of present study is to evaluate the anti ulcer activity of methanol extract of leaves of Nerium indicum. The methanol extract of N. indicum was investigated for its anti ulcer activity against plus pylorus ligation induced gastric ulcer and indomethacin induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity, total acidity, pH and ulcer inhibition in plus pylorus ligation induced gastric ulcer model and mean score value of ulcer inhibition in indomethacin induced ulcer model. A significant antiulcer activity was observed in all the models. Pylorus ligation model showed significant (P<0.001, P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed 69.63 % ulcer inhibition in indomethacin induced ulcer. This present study indicates that Nerium indicum leaves extract have potential anti ulcer activity in the two models tested.