Duloxetine - pharmacological aspects

Duloxetine was developed for the management of depression. This drug was later found to be effective in the treatment of Stress Urinary Incontinence. It exerts its action by blocking the reuptake of serotonin and nor epinephrine in an area of the sacral spinal cord that contains a high density of these neurotransmitter receptors, thus stimulating specific motor neurons that regulate the urethral striated muscle sphincter.