Structural analysis and molecular modeling of Human dopamine receptor 5 (DRD5)

Dopamine has been shown to play a key role in the Central Nervous System. Any imbalance indopamine production and dopamine receptor activity has been implicated widely in the pharmacology, of anumber of neurobehavioral disorders existing today. The dopamine receptors interact with G-proteins totransduce dopamine stimulation into intracellular responses. In this work a 3D structure of DRD5 based onthe template of High resolution crystal structure of human -2 adrenergic receptor (PDB code 2RH1A) wasgenerated. The model was assessed using MOLPROBITY. The results revealed that 94% of the residueswere found in the favoured region of Ramachandran’s plot. Active site analysis showed that predictedbinding sites included all the seven transmembrane helices. Our work demonstrates that in silico modelingof proteins has been shown to play an important role in determining protein structure and provides apromising area in possible drug discovery