Insilico Identification of novel Coding Regions from Archeal Genome -Aeropyrum pernix

Researches on archaeal microorganisms continue to excite the scientific community. Their uniqueadaptations that cater to hypersaline, hyperthermic, and hypothermic circumstances have incited research tomanipulate those attributes for use in virtually every aspect of life. Adaptations in membrane, enzymes, andprotein structures and components have potential applications in areas including electronics, agriculture,aquaculture, medicine, pharmaceuticals, food science, and nutrition. Although the time and effort required tonew find archaeal homologues may be great, many believe that the economic and environmental benefits ofsuch a breakthrough would be considerable enough to outweigh the challenges. An analysis of the archealgenome Aeropyrum pernix, showed that certain regions earlier thought to be ‘non-coding’ have significantsequence similarity to other protein sequences from archaea and other species. The available sequenceanalysis tools were used to identify a number of potential protein coding regions in these putative ‘noncoding’ regions. We could identify 907 such regions and 282 of them apparently code for proteins present inarcheal or other species. The remaining 625 regions are mostly start /stop conflicts. Of the 282 proteincoding regions, only 64 code for proteins with homologues of known function. A good number of proteinsshow homology to proteins that are important for the survival of the organism. Hence these novel regionsmay be referred as homologues to coding regions. In addition Genome sequence collections should beregularly checked to improve gene prediction by sequence similarity and greater effort is required to makegene definitions consistent across related species.