Predictive value of the cow′s milk skin prick test in infantile colic

Background and Objectives : Infantile colic is a common problem among young infants. Cow′s milk allergy has been suggested as one of the causes. We aimed to investigate the value of the cow′s milk skin test for the diagnosis of cow′s milk allergy in exclusively breast-fed infants with infantile colic. Methods : Exclusively breast-fed infants with infantile colic were enrolled in this study. On the first visit, the average hours of crying of the infant in a 24-h period were recorded and the cow′s milk skin test was performed. If the infant had a positive skin test, elimination of cow′s milk from the mothers′ diet was advised. Infants with negative skin tests were divided into case and control groups. Cow′s milk was eliminated from the diet of mothers in the case group. After 2 weeks, the number of hours of crying were recorded again. The reduction in the crying hours was compared between the two groups using the chi-square test. Results : Skin tests were positive in 3 of 114 cases (2.6%) of infantile colic. All three cases recovered completely following elimination of cow′s milk from the mother′s diet. Among the 111 patients with negative skin tests, 77 patients completed the study: 35 in the case group and 42 in the control group. The reduction in crying hours in infants in the case group was not significantly different from that in the control group. Conclusion : Elimination of cow′s milk from the mothers′ diet is not beneficial for infants with a negative skin test. Infants with a positive skin test may benefit from this management.