Function of the CaMK II on LTP of Exercise Learning

This Ca2+/calmodulin-dependent kinase II(CaMKII) is an abundant synaptic signaling molecule that isessential for memory formation and the induction of synapticpotentiation. Additionally, CaMKII plays a prominent role insynaptic tagging and metaplasticity. The kinase becomes activein the presence of calcium and has the potential to switch to anautonomous mode of activity upon auto-phosphorylation. SinceCaMKII can be autonomously active and required for theformation of memory, CaMKII is central to the mechanism ofhippocampal, N-methyl-d-Aspartate NMDA receptordependent long-term potentiation of synaptic transmission(LTP). However, the exact reason increased activity and howthis is worked it is still matter of debate and the exact timewindow of increased activity and how this is terminated, Thereis now overwhelming evident that the expression andsignificance of CaMKII mRNA in hippocampus of rats whosespatial learning and memory function were enhanced byRegular Aerobic Exercise. Thus, regulation of Exercise of theexpression of endogenous CaMKII may constitute importantrole on CaMKII signaling on LTP during memory formation