Kid Goats are More Sensitive to Penicillin Overdose

Hipracilina suspension contains benzyl penicillin (200000I U), dihydrostreptomycin sulfate (250 mg), chlorpheniramine maleate (15 mg) and dexamethasone sodium phosphate (0.6 mg). This drug is used for treatment infection in respiratory, urinary, reproductive, forelimb and hind limb systems in cattle, goats, sheep and rabbits. Hipracilina is intramuscularly injected at dose 1 mL/10 kg body weight once or twice in day for 3 days. Hipracilina was clinically used at dose 1.5 mL/B.W in kid goats. The kids had 6 days age and 3kg weight. These animals had diarrhea after high milk eating. One kids died after 15 min. Fourteen kids had signs such as ataxia, depression, hind limb paralysis, hyperesthesia, mydriasis, decreasing of respiratory rate, tachycardia and falling. Two kids died after 4 h. Supportive treatment was carried by ORS powder and furosemide administration. The kids returned to normal state after 24 h. In another experimental study we divided kids 3 groups which received A: benzyl penicillin, B: benzyl penicillin+dihydrostreptomycin, and C: chlorpheniramine. Group A and B showed depression. Thus, Hipracilina can be toxic in kid goats at nearly 4-5 folds dose. It seems that this toxicity is related to penicillin compound.