LABORATORY MODEL OF CHRONIC STAPHYLOCOCCAL TONSILLITIS

Investigation and development of new preparations for chronic tonsillitis (CT) treatment and prevention requires application of appropriate laboratory model. For the development of CT laboratory model chronic pyoinflammatory process was reproduced in chinchilla rabbits using Staphylococcus aureus 209 Р (АТСС 6538-Р) reference-strain. Preliminary sensitizing of animals with inactivated causative agent and repeated infection with the reference-strain made it possible to work out reproducible model of chronic tonsillitis. Adequacy of chronic tonsillitis development was confirmed by the results of microbiological and pathomorphological researchers. The proposed laboratory model can be used for solving of theoretical and practical medicine and pharmacology topical problems.