Evaluation of Serumal Levels of AST, ALT, Total Bilirubin, Glucose, Urea and Creatinin in Mice after Administration of Tc-99m MIBI

Tc-99m MIBI methoxyisobutylisonitrile (MIBI) is a lipophilic cationic agent which is widely used for myocardial perfusion imaging and also for the detection of various tumors. In present study, for evaluation of serum level of AST, ALT, Total bilirubin, FBC, Urea and Creatinin, 25 mice, respectively were selected and they were divided in 5 groups. 0.3 mC/kg of drug was injected to 4 groups via tail vein. In the control group, before beginning of the investigation bleeding was done. Twenty four hours after injection from the 2nd group, 48 h later from the 3rd group, one week later from the 4th group and two weeks later from the 5th group bleeding was done respectively and the levels of Glucose, Urea, creatinin, ALT, AST and T-bilirubin, respectively were measured using spectophotometr (Biowave S2100 made in England) and diagnostic kits (made in bio-chemistry company, Iran). In Comparison to control group, results had significant differences in serum level of Urea, Creatinin and total bilirubin after 24 and 48 h of administration(p<0.05). Also there were insignificant differences in serum ALT and AST level and Glucose after 24 h of administration in all groups (p<0.05). Results shows that more care is needed for administration of drug in diabetic, renal and hepatic patients.