Design and characterization of orodispersible tablets of Aceclofenac

The aim of this investigation was to prepare orodispersible tablets of Aceclofenac using various concentrations of superdisintegrant agents like croscarmellose sodium, sodium starch glycolate and polyplsadone xl-10 by direct compression method. Seven formulations having superdisintegrants at different concentration levels were prepared. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and invitro disintegration time. Formulation (F4) which shows rapid disintegration contained equal proportion of cross carmellose sodium and polyplasdone xl-10. It was concluded that superdisintegrants addition technique is a useful method for preparing orodispersible tablets by direct compression method. Keywords: Aceclofenac, Orodispersible tablets, Ac-Di-Sol, Crospovidone, Sodium starch glycolate.