Evaluation of Antidiabetic and Antihyperlipidemic Activity of Euphorbia Neriifolia Linn. in High Fat Diet- Streptozotocin Induced Type-2 Diabetic Model

Euphorbia neriifolia Linn. (Euphorbiaceae) is traditionally used to treat diabetes mellitus. The extract of Euphorbia neriifolia Linn. are having potential in the development of drug for diabetes due to their antidiabetic activity. Purpose of the study was to evaluate the antidiabetic activity of ethanolic extracts of leaves of Euphorbia neriifolia Linn. (Euphorbiaceae). The present study was undertaken to evaluate the antidiabetic and antihyperlipidemic effect in high fat diet-streptozotocin (HFD-STZ )induced type-2 diabetic rats. Sprague Dawley rats weighing 200-250 gm were consumed high fat diet (HFD). Two weeks later the animals were given with intraperitonial injection of streptozotocin (STZ) (35mg/kg body weight). The purpose of this study was to examine the effect of repeated oral administration of the ethanolic extract of Euphorbia neriifolia Linn at a dose of (200 and 400 mg/kg) on fasting blood glucose levels and lipid metabolism in streptozotocin induced type-2 diabetic rats. After 21 days of repeated oral administration of 400mg of Euphorbia neriifolia ethanolic extract (ENEE) produced a significant decrease on fasting blood glucose, triglyceride, total cholesterol, LDL levels in HFD-STZ induced type-2 diabetic rats, on the other hand there was significant increase in HDL levels. Glibenclamide 2.5mg/kg,p.o was used as standard drug. In oral glucose tolerance test, reduction of fasting blood glucose levels took place from 60 min of extract administration. We conclude that the ethanolic extract of Euphorbia neriifolia (400mg/kg) exhibits anti diabetic potential along with potent lipid lowering effect after repeated oral administration.