Design and Development of Osmotic Drug Delivery System for Anti-Hypertensive Agent

Controlled porosity osmotic tablet of Atenolol prepared and evaluated in this study. Atenolol is v lowsoluble drug. So it is difficult to formulate osmotic tablet of Atenolol which gives drug release up to 24hr at zero order. To get desired dissolution profile various formulation parameters like osmogenconcentration, level of weight gain and level of pore former concentration were studied. Polysorbate 80was added as solubilizer to increase its dissolution rate and get drug release up to 24 hr at zero order. Asconcentration of solubilizer increases, dissolution rate increases. Final optimized formulation wasstudied for effect of pH of dissolution media, agitation intensity and osmotic pressure of dissolutionmedia. There is no effect of pH of dissolution media and agitation intensity on dissolution. There issignificant effect of osmotic pressure on dissolution confirms that prepared Atenolol tablet gives drugrelease in osmotically control manner.