Synthesis and antimicrobial activity of some new indazolone derivatives from 1-(3,5-Dibromo-2-hydroxy-4 methyl phenyl) ethanone

Indazolone nucleus is present in various therapeutically important drug candidates. Chalcones are possessing versatile pharmacological activities like anti-inflammatory, antifungal, antibacterial, antioxidant, cytotoxic, anticancer, antimalarial. While the bromoacetophenone nucleus bears very good antimicrobial activity. With consideration of all these facts we synthesized new derivatives of bromo acetophenone nucleus, which reacts with aromatic aldehydes to obtained chalcone. This was further derivatized to indazolone. All synthesized compounds were confirmed by spectral data and elemental analysis. The synthesized compounds were screened for antibacterial activity against Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against A. niger. All synthesized compounds showed good to moderate antimicrobial activity.