Synthesis, Characterization and Biological Study of Novel Pyrrole Derivatives

A facile condensation of aromatic aldehydes with 2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)aceto hydrazide (1) was give the corresponding N’-aryl-2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetohydrazide (2a-e) in good yield. Cyclo condensation of compounds (2a-e) with maleic anhydride yields 2-aryl-5-oxo-1-(2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetamido)-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.