MAGNETISABLE IMPLANTS FOR TARGETED DRUG DELIVERY SYSTEM

The capability to deliver high effective dosages to specific sites in the human body has become the holygrail of drug delivery research. Drugs with proven effectiveness under in vitro investigation often reacha major roadblock under in vivo testing due to a lack of an effective delivery strategy. The review articlefocusing on targeted drug delivery by applying high magnetic field gradients within the body to aninjected super paramagnetic colloidal fluid carrying a drug, with the aid of modest uniform magneticfield. A new method for locally targeted drug delivery is proposed that employs magnetic implantsplaced directly in the affected area to attract injected magnetic carriers. Theoretical simulations andexperimental results support the assumption that using magnetic implants in combination with externallyapplied magnetic field will optimize the delivery of magnetic drug to selected sites within a subject.