FORMULATION AND EVALUATION OF FLOATING TABLET OF AMOXICILLIN TRIHYDRATE

The present investigation concerns the design and evaluation of floating tablets of Amoxicillintrihydrate, which after oral administration, are designed to prolonged the gastric residence time and toobtain site-specific drug delivery for the stomach and increased drug bioavailability. Amoxicillin is aSemisynthetic antibiotic, belonging Beta-lactum family, which is effective for bacterial treatment,especially for helicobacter pylori infection. The dosage form was designed by using HPMC K100M,HPMC K15M and HPMC K4M polymers as gelling agents, sodium bicarbonate as gas-generating agentand other excipients. The interaction between drug and excipients in prepared floating tablets werestudied by differential scanning calorimetry (DSC) and FT-IR. Floating tablets prepared by directcompression technique. The prepared floating tablets were evaluated in terms of their pre-compressionparameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drugcontent, swelling index, in-vitro floating studies, in-vitro drug release and short term stability studies..The floating properties and drug release characteristics were determined for the prepared tablets in 0.1 NHCl and water dissolution media. Dissolution Profile was compared with dissolution profile of marketedtablet. The data obtained from in-vitro dissolution studies were fitted in different models. Finaloptimized formulation batch F10 released 93.02% and 73.02% drug in 0.1N HCl and water respectively.