In vivo study of antimutagenic and antioxidant activity of Glycyrrihza glabra root extract

The studying was aimed to inhibition the mutagenecity and oxidation of genomicDNA by use methanol-water extract of Glycyrrihza glabra root (GL) against anticancer drugcyclophosphomide in rats by use DNA fragmentation test, the extract characterized by thinlayer chromatography TLC, and antioxidant activity by use β- carotene spray, the experimentdesign to use tow single dose of GL and single dose of the drug in three interaction, extractbefore, with and after the drug to investigate the mechanism of which extract effect insidecell. Four multiple doses for drug and extract to investigate the accumulation effect in DNAthe results show that extract is contain of different polar compound and have antioxidantactivity, so the extract is bio-antimutagenesis and poor dismutagenesis activity, the extractcan inhibit accumulation effect of mutagenecity and oxidation activity of the drug.