A mini review of pyrimidine and fused pyrimidine marketed drugs

Pyrimidine and its derivatives demonstrate a diverse array of biological andpharmacological activities including anticonvulsant, antibacterial, antifungal, antiviral andanticancer properties. This broad spectrum of biochemical targets has been facilitated by thesynthetic versatility of pyrimidine, which has allowed the generation of a large number ofstructurally diverse derivatives including analogues derived from substitution of the arylring, and/or derivatisation of the pyrimidine nitrogen and C2/C4/C5/C6 carbon positions.Pyrimidines are synthetically versatile substrates, where they can be used for the synthesis ofa large variety of heterocyclic compounds and as raw material for drug synthesis. It wastherefore the objective of this review to systematically evaluate the pharmacologicalproperties of various substituted pyrimidine and collate these findings to be used as a guidefor future structure-activity relationship and mode of action studies. This is the first reviewto comprehensively discuss the pyrimidine and its substituted derivatives.