Unilateral degeneration in hippocampus of female rat

Study demonstrates occurrence of unilateral type neurodegeneration in hippocampal sub region (CA2 andCA4) of female rats that given four hours swimming stress and unique rotational behavior. Stressed rats’ brainsections, stained with cresyl violet, passing through bregma -1.8 to -3.8 levels, demonstrated degenerativechanges in the cell bodies of CA2 and CA4 hippocampal sub regions of right hemisphere. These changeswere observed in 50% of rats. Reason lying behind the unilateral degeneration after exposure to swimmingstress could not be explained. To our knowledge, it is the first report demonstrating unilateral hippocampaldegeneration.