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Research in Pharmacy 2011
Protective effect of bischalcone derivative in Drosophila melanogaster against electron beam radiationKeywords: antioxidant , bischalcone , electron beam radiation , wing shape abnormalities Abstract: In this paper the protective effect of (2E, 5E) – 2,5-bis (3-methoxy-4-hydroxybenzylidene)cyclopentanone bischalcone derivative (Curcumin analogue, CA), onelectron beam radiation induced oxidative stress in Drosophila melanogaster adult flies.Curcumin (CU) was taken as standard. The CA pre treated and irradiated flies werescreened for wing shape abnormalities in F1 and F2 generations. There was considerabledecrease in the wing shape abnormality frequency in the case of CA fed irradiated fliescompared to control.
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