Evaluation of clinical utility of serum enzymes of hepatic origin in clinically affected Marwari sheep of arid tract in India

The clinical utility of serum enzymes of hepatic origin was evaluated by determining theirlevels in the adult sheep of Marwari breed belonging to farmers’ stock of arid tract of Rajasthan state,India. The animals were grouped into healthy and affected which comprised of fasciola infected,pneumonia affected, having enterotoxa122emia, and drought affected. The serum enzymes includedwere sorbitol dehydrogenase, malate dehydrogenase, glucose-6-phosphate-dehydrogenase, glutamatedehydrogenase, ornithine carbamoyl transferase, gamma-glutamayl transferase, 5’nucleotidase, glucose-6-phosphatase, arginase, and aldolase. In clinically affected animals the levels of hepatic serumenzymes were significantly (p≤0.05) higher as compared to respective healthy levels. In fasciolainfected sheep the activities of all the enzymes were higher in comparison to healthy sheep. Degree ofincrease was least in pneumonia affected sheep. The G-6-Pase activity showed comparatively maximumchange in fasciola infected animals as compared to other enzymes. As the activities of all the serumenzymes of hepatic origin were found increased in affected animals, it was concluded that they all haddiagnostic significance exhibiting liver involvement. The increased activity was due to change of liverfunctions directly or indirectly.