Antifertility activity of the aqueous leaf extract of Cissampelos pareira in male albino mice

Aqueous leaf extract of Cissampelos pareira (L) Hirsuta (family Menispermaceae) wasevaluated for the validity of the anti-fertility effect in male mice after oral administration with the extractat dose of 0.5 and 1.0 ml/ 100 gBW daily for 14 days. The significant increment of plasma prolactin anddepletion of follicle stimulating hormone (FSH) in the high dose treated group were found (p<0.05).Interestingly results, the depletion of seminal testicular weight was presented in both treated groupswhereas seminal quality impairment including a decrease in total sperm count and a increase inpercentage of abnormal sperms were shown in the high dose treated group only. The results indicatedthe infertility effect of aqueous Cissampelos pareira leaf extract in male mice occurring after high dose ofextract intake by causing prolactin and FSH disturbance.