Relationship between loss of exercise consequences and risk of cardiovascular diseases after detraining

Background: The studies show that regular exercise may play an important role in improvement the cardiovascular status and with detraining period people will loose its useful outcome. The aim of this study was to assess the effect of short detraining period on cardiovascular biomarkers in Wistar rats.Materials and Method: Forty-two male rats were divided randomly in two groups: experimental group (n=24) and control group (n=18). The training program was done 3 times per week, for 8 weeks. Then six rats experienced detraining. The blood samples were collected after 14 fasting hours in different stages and with the same conditions. The quantity of sICAM-1 was measured, using the commercial R&D Elisa kit. The quantity of total cholesterol (TC), triglyceride (TG), HDL & LDL in plasma was measured by using Pars-Azmoon kits. Data were analyzed by Kolmogrov-Smirnov, repeated measures of ANOVA, LSD and t-test. The amount of errors were computed in the level of p<0.05.Results: Thirty-six sessions of aerobic training made significant changes in variables and after 4 weeks of detraining the amount of measured variables were changed in to the insignificant baseline level. There were significant changes when detraining group compared with training group at the end of study [sICAM-1 (p=0.006), TC (p=0.004), TG (p=0.005) & LDL-C (p=0.037), HDL-C (p=0.037)].Conclusion: The results showed, detraining casuses the increase of dangerous factors and body faces the risk of cardiovascular diseases and atherosclerosis