Chemical Constituents of Two Endemic Sideritis Species from Turkey with Antioxidant Activity

In this study, two Sideritis species, endemic to Turkey, S. niveotomentosa Huber – Morathii, S.brevidens P.H. Davis have been studied for their diterpenic compounds and the antioxidant properties. Eight known diterpenoids, which have ent-kaurene skeleton, were isolated from acetone and methanol extracts of these species. The structures of the isolated diterpenes were determined by using the NMR ( 1H-NMR, 13C-NMR, COSY, HMQC, and HMBC ) spectroscopy. The analysis of the phenolic compounds of the extracts was performed by high performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Also the antioxidant capacity of the extracts was investigated namely by two methods; free radical scavenging and β-carotene bleaching activities.