Implication of genetic factors in osteoporosis susceptibility

Osteoporosis is a multifactorial disease characterized by a decrease in bone mass and deterioration of bone architecture. Genetic factors are determinants of peak bone mass and may influence age-related decreases of bone mass. WHO has established an operational criterion based on bone density measuring, the T-score. 122 cases were studied, 51 diagnosed with primary osteoporosis. Mean age was 57.6 years. The main inclusion criterion was the acceptance of affected individuals to participate in the study. Accurate family history was taken. Daughters of affected persons were evaluated by DEXA technique. 67.2% of them had T-score values that indicated osteopenia or osteoporosis (mean value -2.3SD). In conclusion, descendents of affected parents are at a high risk for osteoporosis, important aspect for primary prevention.