ROLE OF THE GANGLIONIC BLOCKER CHLORISONDAMINE (CHL) IN MEDIATING STRESS INDUCING IMMUNE RESPONSE IN RATS

The involvement of nicotine acetylcholine receptors (nAChRs) was investigated in acute and chronic stress, influence immune system, with concomitant changes in immune response. Adult rats pretreated with 0.5 ml sheep red blood cells (SRBC) (109/ml, Sigma), produce an immune response, and were subjected with chlorisondamine (CHL) (3 mg/kg b.w., i.p.) under acute and chronic stress influence. In the present study, acute stress is a form of short-term stress induced by a single footshock session, and chronic stress is a form of long-term stress induced by multiple and repetitive footshock sessions. 4 days later, we assessed the total number of leukocyte and the antibody titer against SRBC. In summary, we provide the role of ganglionic blocker chlorisondamine in mediating stress-induced immune response in rats.