VITAMIN E INVOLVEMENT IN OXIDATIVE STRESS ASSOCIATED WITH CARCINOGENESIS

Vitamin E is known as a substance with powerful antioxidant proprieties in vivo, along her vitaminic function, her intake reducing the oxidative stress produced by free radicals generators (ORS, etc): ionizing radiations, toxic compounds from air, water, food, etc. It’s well known her effect in numerous human affections, more or less; studies are done over the role & effects in other diseases: diabetes mellitus, cancer, etc. Aim: These researches are following to determine vitamin E effect in carcinogenesis associated OS and so with cancer, vitamin being used as food additive in diet for cancer patients (particularly head and neck cancers used in our study). Following OS reduction, obtaining so, an general status amelioration to subjects, associated with disease, in parallel with specific treatment recommended by medic (chemo- or radiotherapy). We supplementing with vitamin E the food, in calculated doses based on literature studies, with measurements of biochemical parameters in biological fluids from patients as integral blood, serum, plasma and urine – general: glucose, calcium, cholesterol, HDL-cholesterol, triglycerides, creatinine – OS specific: MDA, GSH, SOD, CAT, vitamin E, etc. We use an healthy subjects witness lot which receive an placebo and an witness lot with vitamin E, an subjects lot with cancer receiving an placebo and one with our vitamin E doses, biochemical analysis results up obtained being interpreted, resulting conclusions conducting us to the steps to follow, correlated with results. Expected effect is that one of carcinogenesis (cancer) associated OS reduction, with benefic effects on patient general status.