Bacterial lipopolysaccharide enhanced immunological responsiveness in exposed rats

n order to investigate the effects of the bacterial lipopolysaccharide (LPS) on the brain and serum protein content, LPS was stereotaxically infused into the substantia nigra (SN) of rats at different dosages (3 μg, 10 μg or 250 μg/kg). The results showed that 7 days after neurosurgery there is no variations in brain protein content, while in serum protein content, the amount of gamma-globulins significantly increased compared to sham-operated control rats. The results suggested an immunologic response in the injected rats exposed to the bacterial lipopolysaccharide.