Angiosarcoma - molecular markers in histopathological diagnosis

Angiosarcoma of the breast represents an uncommon entity. This is a case report of a 36-year-old woman who had a primary angiosarcoma of the right breast. After detecting a mass in her breast, she underwent mastectomy. Routine histopathological techique, followed by immunohistochemistry for factor VIII, CD34, vimentin, desmin, and pan- cytokeratin were performed in order to obtain the positive and differential diagnosis. Six months after the surgery, the patient succumbed to multiple metastases. The clinical course corresponded to general poor prognosis of breast angiosarcoma. Vascular targeting approaches in modern therapies represent promising methods for improvement of angiosarcoma's prognosis.