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Molecules  2013 

A New Triterpenoid from Teucrium viscidum

DOI: 10.3390/molecules18011262

Keywords: Teucrium viscidum, triterpenoids, lignans, 11β-HSD1

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Abstract:

A new ursane-type triterpenoid, 3 β-hydroxy-urs-30- p- Z-hydroxycinnamoyloxy-12-en-28-oic-acid ( 1), together with three known triterpenoids, 3 β-hydroxy-urs-30- p- E-hydroxycinnamoyloxy-12-en-28-oic-acid ( 2), 2 α,3 β,19 α-trihydroxy-urs-12-en-28-oic-acid ( 3), and ursolic acid ( 4), four known lignans, pinoresinol ( 5), 9 α-hydroxypinoresinol ( 6), (+)-medioresinol ( 7), and (+)-kobusin ( 8), and two steroids, β-sitosterol ( 9), and daucosterol ( 10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1– 4 were evaluated for their inhibitory activities against 11 β-hydroxysteroid dehydrogenase 1 (11 β-HSD1).

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