Actinomycetes Producing Anti-Methicillin Resistant Staphylococcus aureus from Soil Samples in Nakhon Si Thammarat

A total of 64 different isolates of Actinomycetes were isolated from soil samples in Nakhon Si Thammarat. The anti-MRSA activity of Actinomycetes isolates was examined using agar plug and agar well diffusion methods. It was found that 19 isolates of selected strains showed anti-MRSA activity, there are only 10 isolates, namely, BA2, CK7, CK9, CK11, CO4, WU6, WU7, WU10, WU11 and WU14 which can inhibit all MRSA strains. However, strains tested CK9, CO4, WU6, WU7 and WU10 exhibited the anti-MRSA activities on both agar plug and agar well diffusion methods. The taxonomic studies indicated that the isolates of Actinomycetes CK9, CO4, WU6, WU7 and WU10 belong to Streptomyces sp. CFJ2, Streptomyces antibioticus strain 1022-257, Streptomyces flaveolus strain NRRL B-1334, Streptomyces psammoticus strain NBRC 13971 and Streptomyces sp. b26, respectively. Graphical abstract