Antipyretic activity of seeds from Red and White type of lotus (Nelumbo nucifera) in Albino Rat

Nelumbo nucifera (red and white types) at dose rates of 400 mg/kg and 600 mg/kg was administered orally in rats in which pyrexia was induced with brewers yeast. The standard drug used was aspirin (100 mg/kg). The standard drug showed antipyretic effect from first hour of the study onwards. It was found that during the third hour of the study N. nucifera red and white types, 600 mg/kg showed significant decrease in body temperature. During the fourth hour of the study, all the treatment groups showed antipyretic effect. A similar decrease in body temperature was observed on fifth hour of the study also. Hence the present study revealed that the N. nucifera (red and white types) at the rate of 400 and 600 mg/kg is effective in reducing body temperature in yeast induced pynexia in rats. [Vet World 2009; 2(6.000): 213-214]