How genetically or environmental factors may affect the development of preeclampsia?

Preeclampsia presents itself inall of the world’s populations, with an incidence of 5 – 7%; howeverin developing countries it can be three times greater. In Colombiait is the primary cause of maternal morbidity and mortality, beinga problem of public health. Ethiology of PE is still unknown but it’saccepted that it is a complex disease where individual manifestationsdepends on the interaction of maternal and fetal geneticsand environmental factors. Recently the influence of each ofthese factors on predisposition to develop the disease has triedto be measured. Genetic factors, maternal and fetal, contribute50% towards susceptibility to the condition. General results bya study on Colombian candidate genes in PE, GenPE, supportthese findings, having found the having a familiar history of PE(i.e. mother, sister) are independent risk factors to develop thepathology with OR of 2.74 (IC 95% 1.96-3.83) and 2.37 (IC 95% 1.54-2.63), respectively.