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Comparative activity of some veterinary pharmaceutical products in swine dysentery

Keywords: Brachyspira hyodysenteriae , tiamulins , dimetridazole , efficacy

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Abstract:

One of the diseases that cause great damage in the pig breeding farms, Brachyspyra swine dysentery has a special importance because involve great losses both by growth failure and high mortality andsignificant costs to the prevention and control. The study was conducted in a swine farm in Timis County, where the disease was originally identified in autumn of year 2009. Cumulative adverse conditions have affected the rate of morbidity and mortality. Themost common clinical developments in the unit were usually acute and subacute. Research included: a comparative study of the effectiveness of tiamulin fumarate, hydrogenated and dimetridazole powder in sick acute and subacute forms in piglets, at the weaning period; the comparative study of efficiency in therapy of soluble tiamulin (the tiamulin fumarate-hydrogenated) and of the injection of piglets effective and the study of growth indicators: average daily gain.Experiment IGroup I consisted in 15 piglets with an average weight per lot of 7.60 kg/head (batch weight: 114kg) received p.o. dimetridazole insoluble powder (Romvac Bucharest), mixed in feed, for 5 days dose of 25 mg/kg.bw. During the observation, two mortalities were recorded, representing 13.33% of the treated lot. Other animals from the group were clinically cured, the signs of the disease gradually disappeared, and the temperature returned to normal enteric symptoms. The observation period after the 21 days of experiment, the batchweight was 114.2 kg, corresponding to growth registered 95.5 g/head/day.Group II, of 15 pigs with enteritis clinical signs, have had an average weight per lot of 7.48 kg/head, and he has undergone treatment with tiamulin product (Novartis Animal Health) soluble granules, in drinking water. Treatments were performed for 5 consecutive days at a dose of 60 mg/liter of drinking water. In this group, diarrhea symptoms decreased and general status of the animals gradually improved, no mortality was recorded five days after the treatment, no longer signs of illness being observed, all animals became normothermic. Weight gain recorded on our observation period was 29.3 kg/ lot which correspond to average daily gain of 162.7 g/day/animal.Group III, considered as control group, was at the beginning of the observation period, established with the average weight per lot, of 7.88 kg/head. In this series evolved enteritis with clear clinical manifestations (acute and subacute forms) and during the experiment did not receive any treatment. Within this lot, in the studied period have died five piglets which represent 33.33% of the g

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