Serum Osmolality is Elevated in Metabolic Syndrome Cases

OBJECTIVE: It has previously been shown that renal function is impaired in metabolic syndrome (MetS). Microalbuminuria, elevated serum osmolality, and decreased glomerular filtration rate (GFR) may indicate some degree of renal impairment. Among these, microalbuminuria and GFR have already been shown to be related with MetS. This study aimed to investigate the relation between MetS and serum osmolality.MATERIAL and METHODS: A cross-sectional case control study was designed. The study group was composed of 115 persons who were diagnosed as having MetS according to ATP III criteria and 123 persons who did not have MetS. The diagnosis of MetS was based on the presence of three or more of the following factors: hypertension; abdominal obesity; fasting serum triglycerides; low high-density lipoprotein (HDL)-cholesterol and fasting plasma glucose. Serum osmolality and GFR values were estimated by using appropriate formulations.RESULTS: A total of 238 persons aged between 18-65 years were included in the study. MetS and serum osmolality were significantly correlated (P=0.001). Serum osmolality was also correlated with systolic blood pressure (P=0.000), fasting plasma glucose (P=0.000), and waist circumference (P=0.000).CONCLUSION: Serum osmolality is correlated with metabolic syndrome and its parameters. The reason for increased serum osmolality values in MetS patients needs to be investigated.