Evaluation of multiple primary tumors and single tumors charecteristics: a study from hospital-based cancer registry in zmir

OBJECTIVES: To evaluate patients with multiple primary tumors (MPTs) from the data of Izmir Cancer Registry (ICR) in Izmir Atatürk Research and Training Hospital (IAEAH) and to compare them with single tumor (ST). METHODS: 572 multiple primary tumors (MPTs) (286 patients) out of 20.895 tumors recorded during the period of 1993-2005 by office of ICR located in IAEAH were analyzed. Double tumors (DTs) were analyzed. Chi-square test and Independent Samples t-test were performed by SPSS 10.0. RESULTS: Of patients with MPTs 53.2% had synchronous whereas 43.1% had metachronous. The mean age were 55.81±15.4 years for ST group; 61.49±13.32 for DT group (p<0.001). Urogenital tumors (30.9%) and skin tumors (17.1%) in DTs group were higher than ST group statistically. The mean interval of DT was 44.4±30.82 (38.99-49.77) months. CONCLUSION: Field cancerization, theory of a common clonal origin or screening effect may account for the relatively frequent association of urogenital tumors.