The value of the expressions of E-cadherin, Calretinin and GLUT-1 in the differential diagnosis of malignant mesothelioma, reactive mesothelial proliferation and adenocarcinoma in serous effusions

OBJECTIVES: The aim of the study was to establish the value of E-cadherin, Calretinin and GLUT-1 antibodies in serous effusions in the differential diagnosis of malignant mesothelioma, reactive mesothelial proliferation and adenocarcinoma using immunocytochemical method. METHODS: The study group consisted of the cell blocks from 60 patients, with 20 in each of the three groups. Immunocytochemistry staining method was applied to the sections prepared from the cell blocks of the selected cases. RESULTS: In this study, strong expression of E-cadherin antibody in adenocarcinoma, strong expression of Calretinin antibody in mesothelioma and reactive mesothelial proliferation, and strong expression of GLUT-1 antibody in mesothelioma and adenocarcinoma were established. CONCLUSION: The results of the present study revealed that E-cadherin antibody can be successfully used as a marker for the differentiation of adenocarcinoma from mesothelioma and reactive mesothelial proliferation, Calretinin antibody can be used for the differentiation of mesothelioma and reactive mesothelial proliferation from adenocarcinoma, and GLUT-1 antibody can be used for the differentiation of adenocarcinoma and mesothelioma from reactive mesothelial proliferation.