Superdisintegrant Selection for Tramadol Dispersible Tablets Superdisintegrant Selection for Tramadol Dispersible Tablets

The selection of a suitable superdisintegrant for a rapidly disintegrating dosage form is of utmost importance, since disintegration time is a critical parameter. An experimental design was designed so as to find out the effect of superdisintegrants (sodium starch glycollate, crospovidone, croscarmellose sodium and Methacrylic copolymer with divinyl benzene) at 2, 4, 6% w/w and its effect on hardness with respect to disintegration time. 4% w/w methacrylic copolymer with divinyl benzene is selected as the best superdisintegrant, effective enough for Tramadol. With increase in hardness, there was a considerable increase disintegration time with all concentrations of superdisintegrants. Crospovidone and Methacrylic copolymer with divinyl benzene in combination showed a remarkable drop in disintegration time upto 0.33 min. Stability Studies of the batch with lowest disintegration time was also carried out and suggests that there was no degradation with respect to time. The selection of a suitable superdisintegrant for a rapidly disintegrating dosage form is of the utmost importance, since disintegration time (DT) is a critical parameter. An experimental design was implemented, to find out the effects of superdisintegrants (sodium starch glycolate, crospovidone, croscarmellose sodium and methacrylic copolymer with divinyl benzene), at 2, 4, 6% w/w, on tablet hardness, with respect to DT. Methacrylic copolymer with divinyl benzene (at 4 wt%) was selected as the best superdisintegrant, adequate for the formulation of dispersible Tramadol tablets. With increasing hardness, there was a considerable increase in DT at all concentrations of superdisintegrants. A combination of crospovidone and methacrylic copolymer with divinyl benzene showed a remarkable drop in DT to 0.33 min. The stability of the batch with lowest DT was also tested under various conditions and the results suggested that there was no degradation over the test period. Keywords: Tramadol. Sodium Starch Glycolate. Crospovidone. Croscarmellose Sodium. Superdisintegrants.