Association Between C Reactive Protein and Asthma

Objective: Reported studies have found an inverse relationship between lung function and markers of systemic inflammation. The aim of this study was to clarify the relationship between C-reactive protein (CRP) serum levels, body mass index and asthma. Material and Method: In the present study, CRP was determined in 178 patients with asthma and 50 healthy control subjects. Of all asthmatics, 126 had stable asthma and 52 had asthma during exacerbation. Results: CRP was significantly higher (p<0.05) in asthmatic patients as compared to the control group. In asthmatics with exacerbation, serum CRP was significantly higher than in stable asthmatic patients and control subjects. FEV1 was significantly inversely correlated with serum CRP in asthmatic patients. In asthmatic patients there was a significant (p<0.0001) association between serum level of CRP and body mass index. Furthermore, the mean BMI was significantly higher in asthmatic patients than that in control subjects. Conclusion: Serum CRP may be a non specific marker of asthma and its exacerbation. In addition, obesity could be a risk factor for asthma.