Injection of Autologous Cultured Fibroblast for the Treatment of Acne Scars

Background and Design: Acne scars on the face are still an important cosmetic problem. In this study, we aimed to determine the efficacy and safety of intradermal injections of autologous fibroblasts for the treatment of acne scars. Materials and Methods: This was an open, prospective, phase 3, pilot study. Six adults with acne scars (4 male, 2 female; age range: 21- 35 years) were included in this study. Autologous cultured fibroblasts (20 million/ml) were given as two doses administered with two weeks interval. Efficacy evaluation was performed 2, 4, 6, and 12 months after the first injections. Subjective improvement scores were noted by patient and clinicians at every follow-up visit. Results: An improvement in acne scars of more than 50% was observed in two of the 6 at 6 months while five of the 6 patients and clinicians also noted 50% to 75% improvement with the treatment at 12 months. The best results were obtained at 12 months. No serious side effects were detected. Conclusion: In this pilot study, intradermal injections of autologous fibroblast were found to be effective and safe for acne scars.