Tuberosclerosis cases presenting with cardiac mass during the neonatal period

The aim of the study is to evaluate the tuberosclerosis cases diagnosed during the neonatal period presenting with cardiac masses. The clinical and laboratory findings of 4 cases and of tuberosclerosis diagnosed in Ege University Medical Faculty Newborn Clinic were evaluated retrospectively. The first case was admitted to the Newborn Clinic with the diagnosis of cardiac mass detected at the 28th gestational week. Cranial magnetic resonance imaging revealed subependimal hamartomas. Echocardiography showed large masses within the intraventricular cavity and cardiac apex. The second case was admitted to the Newborn Clinic with the diagnosis of cardiac mass detected at the 29th gestational week. Cranial magnetic resonance imaging revealed subependimal hamartomas and cortical tubers. Echocardiography showed multiple masses located at right ventricular outflow, right atrium and left ventricule. In the third case multiple cardiac masses in both ventricules were detected during the neonatal period. Cranial magnetic resonance imaging showed multiple tubers. The fourth case was admitted to the Newborn Clinic with the diagnosis of cardiac mass detected at the 32th gestational week. Three hipopigmented skin lesions were found. Echocardiography showed multiple masses within the right ventricle, left ventricle and interatrial septum. Cranial magnetic resonance imaging revealed subependimal nodules. Cardiac mass should suggest Tubeous Sclerosis, cranial imaging must be performed. (Turk Arch Ped 2013; 48: 57-61)