Application of Membrane-Selective Electrodes for the Determination of Naftidrofuryl Oxalate in the Presence of Its Alkaline Degradant in Tablets and Plasma

Membrane selective electrodes were used to determine Naftidrofuryl Oxalate (NFL) in presence of its alkaline degradate (I). The membrane selective electrodes include construction of water insoluble ion-association complexes. These are NFL-tetraphenyl borate (NFL-TPB), NFL-reinikate (NFL-R). These complexes are used as electroactive materials, in poly-vinyl chloride (PVC) matrix membrane sensors, for the determination of NFL. The performance characteristics of these sensors, evaluated according to IUPAC recommendations, reveal fast, stable and linear response for NFL. The sensors are used for determination of NFL in plasma. The suggested method was used to determine NFL in synthetic mixtures and in commercial tablets. The obtained results were statistically compared with official HPLC method, showing no significant difference with respect to accuracy and precision.